interop When not to use Register for COM interop?

interop When not to use Register for COM interop?: "I have a solution with several .NET assemblies that are required to be

COM registered for use in C++, VB, Delphi etc.

I have the 'Register for COM Interop' build setting set to true.
However this causes problems with DLLs being cached in the
'C:\Documents and Settings\jjboswel\Local Settings\Application
Data\assembly\dl2\' subfolders (as reported in other threads).
So periodically if we see strange debugging problems we delete our
cache folder and everything works again.